In Dish Challenge the player must survive wave after wave of enemy attacks while attempting to score combos for points. There are two different game modes besides the Story Mode. Upon defeat, the Dishwasher cuts the Doctor's head clean in two. He recognizes the Dishwasher instantly upon confrontation and claims that he is "property"-nothing more.
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Distraught at her death, the Dishwasher's hatred grows ever stronger. She thanks him with her dying breath for "saving her". Whilst pursuing Synthesis, the Dishwasher is accosted by a masked assassin in Grace Chapel: the Dishwasher quickly disposes of his enemy only for the assassin's hood to fall and reveal the face of his sister. He often reminisces of his sister but thinks she is dead.
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The Dishwasher has flashbacks through a series of comic-strips about his life and hatred for the Cyborgs and their master "Synthesis AI" but more importantly of his sister, Yuki, who gave herself willingly to the Cyborgs. The Dishwasher: The hyperviolent, unnamed protagonist killed by the Cyborgs in hopes of making him one of their own, the Dishwasher was saved by Chef-his mentor-who infused him with Alien Blood, resurrecting him and giving him incredible powers.Also present is a guitar minigame, which can be played with the common guitar peripherals from the Guitar Hero and Rock Band series. There is also a magic system, dubbed "Dish Magic", which can be bought at later levels. Enemies, once weakened, are susceptible to various "finishing moves" that yield even more points and health to the player.
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Fighting is done through using either a basic attack, a strong attack, or a grab move, in combination or alone to string together chains of attacks for points. Weapons include the cleavers, a katana, an Uzi/shotgun combo, chainsaw, and kama. The player is given a basic starting weapon (meat cleavers) and can earn new weapons and upgrades by defeating bosses and collecting "spirals" from defeated enemies. Gameplay revolves around an unnamed protagonist, ostensibly a dishwasher, as he fights through waves of increasingly stronger enemies until the boss fight and the end of the level.